The Dr. Bert L. Schram Young Investigators' Mini-Symposium

Sponsored by the ESCOM SCIENCE FOUNDATION
Chairs: John P. Mayer and Alain Fournier

CAGED PHOSPOSERINE PEPTIDES AND PROTEINS
Deborah Rothman - Barbara Imperiali
Massachusetts Institute of Technology

INTERACTION BETWEEN A MINIMUM HEVEIN DOMAIN AND CHITOOLIGOSACCHARIDES STUDIED BY NMR AND A NOVEL SURFACE PLASMON RESONANCE METHOD
Miquel Vila-Perello - Nuria Aboitiz - Ricardo Gutiérrez-Gallego - Francisco Javier Canada - Jesus Jimenez-Barbero - David Andreu
Department of Experimental and Health Sciences; Universitat Pompeu Fabra; Centro Investigaciones Biológicas-CSIC; Pharmacology Unit; IMIM

CROSS-REACTIVITY STUDIES OF rMOGED WITH SYNTHETIC PUTATIVE AUTOANTIGENS CSF114(Glc) AND [N31(Glc)]hMOG(30-50) IN MULTIPLE SCLEROSIS PATIENTS' SERA
Barbara Mulinacci - Constanz Breithaupt - Prajna Paramita Pal - Nediljko Budisa - Marta Pazzagli - Benedetta Mazzanti - Paolo Rovero - Luis Moroder - Anna Maria Papini
Laboratory of Peptide & Protein Chemistry & Biology; Polo Scientifico; University of Florence; Max-Planck-Institut für Biochemie; D-82152 Martinsried; Germany.; Laboratory of Peptide & Protein Chemistry & Biology.; Laboratory of Peptide & Protein Chemistry & Biology; Università di Firenze.

SITE SPECIFIC INTRODUCTION OF UNNATURAL AMINO ACIDS AT SITES CRITICAL TO INSULIN RECEPTOR RECOGNITION AND BIOLOGICAL ACTIVITY
Beili Quan - Dave Smiley - Vasily Gelfanov - Richard DiMarchi
Indiana University

HELICAL PEPTIDE ANALOGS OF GP41 TO DEVELOP AN HIV VACCINE
Florence Brunel - Michael Zwick - Dennis Burton - Phil Dawson
The Scripps Research Institute; Department of Immunology; The Scripps Research Institute; La Jolla; CA; 92037; U.S.A.; Department of Chemistry; The Scripps Research Institute; La Jolla; CA; 92037; U.S.A.

NMR STRUCTURE OF C-TERMINAL PEPTIDE FRAGMENTS FROM E COLI OSMOREGULATORY PROTEIN PROP
David Zoetewey - Janet Wood - Robert Hodges
University of Colorado Health Sciences Center; University of Guelph Canada

PEPTIDE-DERIVED (SULFONYL) AZIDES AS VERSATILE SYNTHONS IN CHEMOSELECTIVE BIOCONJUGATIONS
Remco Merkx - Dirk TS Rijkers - Arwin J Brouwer - J. Kemmink - RMJ Liskamp
Department of Medicinal Chemistry; Utrecht Institute for Pharmaceutical Sciences; Utrecht University; P.O. Box 80082; 3508 TB Utrecht; The Netherlands

DESIGN AND SYNTHESIS OF PIPERAZINE-BASED SMALL MOLECULE PEPTIDE MIMETICS TARGETING THE MELANOCORTIN RECEPTORS
James Cain - Alexander V. Mayorov - Yeon-Sun Lee - Minying Cai - Jinfa Ying - Victor Hruby
University of Arizona

REFRESHMENT BREAK IN LECTURE HALL

BASIS FOR SELECTIVITY OF CATIONIC ANTIMICROBIAL PEPTIDES FOR BACTERIAL VS. MAMMALIAN MEMBRANES
Evgenia Glukhov - Charles M. Deber
Structural Biology & Biochemistry; Research Institute; Hospital for Sick Children; Toronto; Ontario; Canada

TOTAL SOLID PHASE SYNTHESIS OF THE MARINE CYCLODEPSIPEPTIDE IB-01212
Luis J. Cruz, Marta Martinez, Julia Perez, Marta Trujillo, Ricard Rodriguez, Ernest Giralt, Carmen Cuevas, Librada M Cañedo, Fernando Albericio
Barcelona Science Park; University of Barcelona; 08028-Barcelona; Spain; Instituto Biomar S. A.; 24231 Onzonilla; León. Spain; Phama Mar; 28770-Colmenar Viejo; Madrid; Spain

STUDY OF FUNCTION(S) AND POSSIBLE DESTABILIZING MECHANISMS OF WILDTYPE OP18/STATHMIN AND MUTANT Q18--E IN MICROTUBULE DYNAMICS.
Hope Wilson - Douglas A. Thrower - Leslie Wilson
California Alliance for Minority Participation (CAMP)

A NEW CLASS OF BETA STRAND MIMETICS
John Blankenship - William D. Lubell
University of Montreal

SELF-ASSEMBLED HYDROGELS FROM B-HAIRPIN PEPTIDES: TUNING RESPONSIVENESS AND BULK MATERIAL PROPERTIES BY PEPTIDE DESIGN
Karthikan Rajagopal - Bulent Ozbas - Darrin Pochan - Joel Schneider
University of Delaware

CELLULAR UPTAKE OF CELL-PENETRATING PEPTIDES (CPP) IS DIFFERENTIATION RESTRICTED
Christina Foerg
Institute of Pharmaceutical Sciences; Swiss Federal Institute of Technology Zurich (ETH Zurich)

IN VITRO TRANSLATION OF ALL-UNNATURAL PEPTIDES
Matthew Hartman - Kristopher Josephson - Jack Szostak
Howard Hughes Medical Institute; Massachusetts General Hospital; Harvard Medical School

Young Investigators' Poster Competition

Sponsored by the CS Bio Co.

THIOHYDANTOINS - A TECHNIQUE FOR LABELLING PEPTIDES AND PROTEINS
Carole Bruckler - Mark Bradley

A DIMERIZATION 'SWITCH' IN THE INTERNALIZATION MECHANISM OF A CELL-PENETRATING PEPTIDE
Jason Moss - Antonietta Lillo - Changshou Gao - et al.

SELF-ASSEMBLED ƒÒ-SHEET HYDROGELS: EFFECT OF STRAND NUMBER ON THE FOLDING AND CONSEQUENT SELF-ASSEMBLY OF PEPTIDES INTO HYDROGEL MATERIAL WITH TUNED PROPERTIES
Ronak Rughani - Darrin Pochan - Joel Schneider

PHOTODIMERIZATION IN SUBSTITUTED DI- AND OLIGOPEPTIDES BY UV-LIGHT FOR OPTICAL DATA STORAGE.
Brian Lohse - Rolf Berg

INFLUENCE OF THE NUCLEOPHILICITY AND ELECTROPHILICITY PROPERTIES OF SOLVENTS FOR PEPTIDE SOLUBILIZATION: CD MONITORING AND THE SPECIAL EFFECT OF THE WATER MOLECULE
Luciana Malavolta - Clóvis Nakaie

VCD Spectroscopic Analysis of the Truncated Exendin-4 Analog TC5b
Jeffrey Copps - Richard Murphy - Sandor Lovas

TYPE II b-TURN FORMATION IN TETRAPEPTIDES REVEALED BY VIBRATIONAL CIRCULAR DICHRIOISM SPECTROSCOPY
Attila Borics - Richard F. Murphy - Sandor Lovas

STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF A NOVEL AGRP-MELANOCORTIN CHIMERIC TEMPLATE
Krista Wilson - A. Wilczynski - J.W. Scott - et al.

SOLID-PHASE SYNTHESIS OF AZA-PEPTIDES USING ACTIVATED FMOC-AZA-AMINO ACID
Damien Boeglin - William D Lubell

IDENTIFICATION OF A HIGH POTENCY GLUCAGON AGONIST WITH ENHANCED BIOPHYSICAL STABILITY AND AQUEOUS SOLUBILITY
Katie Traylor - Dave Smiley - Vasily Gelfanov - et al.

DESIGN AND SYNTHESIS OF BICYCLIC INTERNAL â-TURN MIMETICS AND THEIR APPLICATIONS TOWARD BIOLOGICALLY INTERESTING LIGANDS
Byoung J. Min - Xuyuan Gu - Yeon S. Lee - et al.

Synthesis and Incorporation of Freidinger Lactam Analogs in GHRP-6
Fabrice Galaud - William D. Lubell

The conformational preference of C-alpha centered protein radicals
Michael Owen - Richard Murphy - Sandor Lovas

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF A NEW GENERATION OF TIPP-DERIVED DUAL-LABELED LIGANDS FOR DELTA OPIOID RECEPTORS
Xin Wang - Thomas Murray - Jane Aldrich

MICROWAVE-ASSISTED SYNTHESIS OF GLYCOSYLATED BUILDING BLOCKS
Ilaria Paolini - Francesca Nuti - Irene Matteini - et al.

OPTIMIZED CONDITIONS FOR GLYCOPEPTIDE SYNTHESIS BY A MICROWAVE PEPTIDE SYNTHESIZER
Giuseppina Sabatino - ILARIA PAOLINI - MARICRUZ POZO-CARRERO - et al.

ASPARAGINYL GLUCOSE IS FUNDAMENTAL FOR AUTOANTIBODY RECOGNITION IN MULTIPLE SCLEROSIS
Francesca Nuti - Ilaria Paolini - Benedetta Mazzanti - et al.

Synthesis and Pharmacological Evaluation of Dual Labeled Delta Opioid Receptor Peptides
Angela Peck - Vivek Kumar - Thomas Murray - et al.

FISHING FOR ANTIGENS RECOGNIZING AUTOANTIBODIES IN MULTIPLE SCLEROSIS
Maria Claudia Alcaro - Paolo Rovero - Anna Maria Papini

Probing Backbone Amide Hydrogen Bonding in Beta-Amyloid Aggregation by Chemical Synthesis and Mass Spectrometry
Jason Moss - Jason Chang - Christopher Manz - et al.

NOVEL RETRO-INVERSO ENVELOPE PEPTIDE MIMETIC FUSION INHIBITORS AS A POTENTIAL THERAPY FOR HTLV-1 INFECTED INDIVIDUALS
Sharad Rawale - Steven Jacobson - Pravin Kaumaya - et al.

PARALLEL SOLID-PHASE SYNTHESIS OF MUCIN-LIKE GLYCOPEPTIDES FROM AN á-GalN3 O-LINKED THREONINE BUILDING BLOCK
Mian Liu - George Barany - David Live

DESIGN AND SYNTHESIS OF TYPE II'' b-TURN CONSTRAINED SOMATOSTATIN ANALOGS
Audrey Kelleman - Hao Huang - Giuseppe Melacini - et al.

PROTEOME CHARACTERIZATION USING FLUOROUS AFFINITY ENRICHMENT AND MASS SPECTROMETRY
Scott Brittain - Ansgar Brock - Daniel Mason - et al.

RIBOSOMAL SYNTHESIS OF UNNATURAL PEPTIDES
Mattew Hartman - Jack Szostak - Kristopher Josephson

IN VITRO TRANSLATION OF ALL-UNNATURAL PEPTIDES
Matthew Hartman - Kristopher Josephson - Jack Szostak

Synthesis of Silyl Ether Linkers for Solid Phase Synthesis
Rita S. Majerle - Cassidy Dobson - George Barany

CHARACTERIZATION OF THE TRANSPORT OF SUBSTANCE-P ACROSS BLOOD-BRAIN BARRIER
Arvind Chappa - Kenneth Audus - Susan Lunte

SYNTHETIC ROUTES TO AND MECHANISTIC UNDERSTANDING OF; DITHIASUCCINOYL (DTS)-AMINES AND CHLOROCARBONYL CARBAMOYL DISULFANES
Michael Barany - Megan Corey - Michael Hanson - et al.

PEPTIDE-DERIVED (SULFONYL)AZIDES AS VERSATILE SYNTHONS IN CHEMOSELECTIVE BIOCONJUGATIONS
R. Merkx - Dirk TS Rijkers - A.J. Brouwer - et al.

IMPACT OF A SINGLE alpha alpha-DISUBSTITUTED AMINO ACID ON beta-HAIRPIN FOLDING
Larry R. Masterson

HETEROCLITIC ANALOGUES AGAINST HTLV-1 ANTIGENS INCREASE CYTOLYTIC AND IFN-ã RESPONSES IN HLA-A*0201 TRANSGENIC MICE
Danielle Carbin - Sharad Rawale - Jacqueline Lieblein - et al.

DIFFERENTIATION OF AGONISTS AND ANTAGONISTS AND CELL TRAFFICKING AND SIGNALING OF HUMAN MELANOCORTIN RECEPTORS IN REAL TIME USING TWO-PHOTON FLUORESCENCE AND CONFOCAL LASER SCANING MICROSCOPY
Minying Cai - Eva Varga - Henry Yamamura - et al.

RGD-CY7 CONJUGATE AS FLUORESCENCE PROBE TO IMAGE áVâ3 INTEGRIN EXPRESSION IN BRAIN TUMOR XENOGRAFTS
Yun Wu - Xiaoyuan Chen

METHOD FOR CHARACTIZATION PICO-SCALE PHOTOREACTION IN BULK SOLUTION CONTAINING PHOTOGENERATED REAGENTS EMPLOYED IN PARALLEL MICROARRAY SYNTHESIS
Wu Yao - Jean Philippe Pellois - Xiaochuan Zhou - et al.

SYNTHESIS OF NEOLIPOPEPTIDES BY CHEMOSELECTIVE ACYLATION AND ALKYLATION OF N-ALKYLAMINOOXY-CONTAINING PEPTIDES
Marisol Sweeney - Oscar Silva - Katherine Rawls - et al.

Efficient Synthesis of Beta-Peptide Combinatorial Libraries with Microwave Irradiation
Justin Murray - Sam Gellman

DEVELOPMENT OF A MONOCLONAL ANTIBODY THERAPEUTIC FOR THE PREVENTION AND TREATMENT OF PSEUDOMONAS AERUGINOSA INFECTION
Daniel Kao - Robert Hodges

AN UNEXPECTED SIDE REACTION INVOLVING THE DELETION OF AN ACETYLATED N-METHYL-AMINO ACID FROM THE N-TERMINUS OF PEPTIDES
Wei-Jie Fang - Marco A Bennett - Thomas F Murray - et al.

Multivalent Chemical Constructs of the Ca2+ binding module of Annexin-V for Targeted Molecular Imaging
Cheng Yim - Tilman Hackeng

PHOSPHOPEPTIDE PROTEOMICS WITH ON-BEAD CHEMICAL SYNTHESIS AND DISPLAY
Malene Brandt - Steen Gammeltoft - Knud J. Jensen

COMBINATORIAL APPROACH TO DEVELOP THE OPTIMAL GLYCOPEPTIDE AS MOLECULAR PROBE TO CHARACTERIZE AUTOANTIBODIES IN MULTIPLE SCLEROSIS
Elisa Peroni - Maria Claudia Alcaro - Francesca Barbetti - et al.

FUNCTIONAL MIMICRY OF AN ALPHA-HELICAL BINDING EPITOPE WITH BETA-HAIRPIN PEPTIDES
Rudi Fasan - Peer R.E. Mittl - Ricardo L.A. Dias - et al.

UNEQUIVOCAL SYNTHESIS OF (Z)-ALKENE OR (E)-FLUOROALKENE DIPEPTIDE ISOSTERES VIA DKP MIMETICS TO PROBE STRUCTURAL REQUIREMENTS OF PEPTIDE TRANSPORTER
Ayumu Niida - Shinya Oishi - Makiko Mizumoto - et al.

DEVELOPMENT OF NEW PHOTOREMOVABLE AMINO PROTECTING GROUP AND ITS APPLICATION TOWARD CHEMICAL SYNTHESIS OF 7TM-GPCR
Satoshi Ueda - Akira Otaka - Hirokazu Tamamura - et al.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CHIMERIC BIOACTIVE PEPTIDES BASED ON AMINO ACIDS COUPLED TO 4-ANILINO-N-PHENETHYL-PIPERIDINE
Ravil Petrov - Ruben Vardanyan - Ma Shou-wu - et al.

ANTIPROLIFERATIVE EFFECT OF LAMPREY GONADOTROPIN-RELEASING HORMONE III ON CANCER CELLS FROM NON-REPRODUCTIVE ORGANS.
Richard Murphy - Sandor Lovas - Krisztina Heredi-Szabo

INTERFERENCE WITH PROTEIN-PROTEIN INTERACTIONS INVOLVED IN PROTEASE-INHIBITOR COMPLEX FROMATION
Dirk-Jan van Zoelen - Prof. Dr. M.R. Egmond - Dr. R.J. Pieters - et al.

Multivalent Peptide Dendrimers
Hinke Malda - Marcel van Genderen - Tilman Hackeng - et al.

Design and Synthesis of Target-Specific Contrast Agents
Anouk Dirksen - Sander Langereis - Bas de Waal - et al.

Novel Gene sequences of cyclotides
Lillian Sando - Rehka Bharati - David Craik

DETERMINATION OF INHERENT HYDROPHILICITY OR HYDROPHOBICITY COEFFICIENTS FOR AMINO ACID SIDE-CHAINS IN THE ABSENCE OF NEAREST-NEIGHBOUR EFFECTS
James Kovacs - Colin Mant - Robert Hodges

Fluorescent Probes of Protein Kinase Activity
Melissa Shults - Barbara Imperiali

IDENTIFICATION OF LIPOXYGENASE INHIBITORY PEPTIDES FROM ß-CASEIN USING SPOT SYNTHESIS
Marloes Schurink - Willem van Berkel - Harry Wichers - et al.

PREVENTION OF AMYLOID FORMATION BY NATURAL PEPTIDES: THE MOLECULAR MECHANISM OF IAPP AND INSULIN INTERACTION
Sharon Gilead - Ehud Gazit

HYDROPHOBICITY AFFECTS b-HAIRPIN HYDROGELATION
Christopher Micklitsch - Karthikan Rajagopal - Tuna Yucel - et al.

TEMPLATE-ASSEMBLED PEPTIDE MODELS OF THE N-PEPTIDE HELIX BUNDLE FROM HIV-1 GP41
Weiming XU - John Taylor

DISCOVERY OF POTENT mMC1R AGONISTS WITH PROLONGED ACTIVITY AT HUMAN MELANOCYTES
Aleksandar Todorovic - Jerry Ryan Holder - Rayna Bauzo - et al.

OLIGOUREA FOLDAMERS AS ANTIMICROBIAL PEPTIDOMIMETICS
Aude Violette - Marie-Christine Petit - Didier Rognan - et al.

Synthesis and Use of C-Terminally Biotinylated Peptidomimetics with High Grb2 SH2 Domain-Binding Affinity
Zhen-Dan Shi - Pathirage Dharmawardana - Alessio Giubellino - et al.

DESIGN AND SYNTHESIS OF NOVEL CHROMONE BASED
Kristian Dahlen - Morten Grötli - Kristina Luthman